DomainOS Engines
Every DomainOS engine reachable from the Hordago router is documented here with the same 8-section contract, generated from its domain-os.yaml manifest by scripts/gen_domainos_docs.py. Sections: Overview, Scientific approach, Capabilities & evidence objects, Standalone quickstart, Worked example, Validation & benchmarks, Reference, and Composition.
Coverage: 12 DomainOS engines with uniform pages. Each quickstart is standalone (zero platform dependency); Hordago platform composition is opt-in per page.
Production
| Product |
Engine |
Domain |
Page |
| CRISPRos |
crispr-system |
CRISPR gene editing (wet lab -> dry lab design) |
CRISPRos |
| GWASos |
gwas-os |
Statistical genetics (GWAS + post-GWAS + fine-mapping + PRS) |
GWASos |
| MLos |
aiDevops |
Deep learning for genomics (Karpathy 6-phase methodology) |
MLos |
Graduated (production, ADR-009)
| Product |
Engine |
Domain |
Page |
| BIOos |
bioinformatics-os |
Evidence-locked AI bioinformatician (general dry-lab workbench) |
BIOos |
| microbiome-os |
microbiome-os |
Microbial communities (16S, metagenomics, amplicon, resistome) |
microbiome-os |
| onco-os |
onco-os |
Cancer genomics (somatic variants, neoantigen, TMB, DepMap dependencies) |
onco-os |
| prs-os |
prs-os |
Polygenic risk scores (LDpred, PRSice, cross-ancestry transfer) |
prs-os |
| rare-os |
rare-os |
Rare disease / Mendelian (ACMG, de novo, exome diagnosis) |
rare-os |
Scaffold (routing wired, skills pending)
| Product |
Engine |
Domain |
Page |
| clinical-os |
clinical-os |
EHR analytics (MIMIC, eICU, OMOP, PyHealth) |
clinical-os |
| QTLos |
hordago-qtlos |
Molecular QTL mapping (eQTL, caQTL, mQTL, haQTL, allelic imbalance) |
QTLos |
| screen-os |
screen-os |
CRISPR & perturbation screens (MAGeCK, dropout, essentiality) |
screen-os |
| struct-os |
struct-os |
Protein structure (AlphaFold, RosettaFold, docking, molecular dynamics) |
struct-os |